The Type 1 Diabetes Resource
The NIDDK sponsored Type 1 Diabetes Resource (T1DR) at The Jackson Laboratory supports Type 1 Diabetes research by serving as an international repository for importation, curation, genotypic and phenotypic validation, cryopreservation, and distribution of mouse stocks of value to the scientific community.
The T1DR currently holds over 250 genetically modified or congenic mouse stocks that are being used to dissect genetic and biologic features of T1D.
An added value of T1DR stocks is their ability to propel advances in related areas of science, including research in non-T1D autoimmunity and infectious diseases. Our staff provides information and technical assistance regarding selection and use of existing T1DR models, and will provide limited support for development of new models considered to be of high-value for the T1D community.
Over the next five years this major NIDDK-directed collaborative effort will have an increased emphasis on preclinical research model development. Expanded T1DR activities will be focused on development/refinement of mouse models expressing HLA or other molecules associated with disease susceptibility in patients, and on the use of these stocks to support engraftment with human immune cells or other tissues.
Proposals for construction of new "humanized" mouse stocks
The T1DR through an NIDDK-supported program for the external scientific community to submit proposals for collaborative construction of new "humanized" mouse models or refinement of existing models such as the NSG mouse. The goal is to enhance the value of such models for studying T1D and potentially other organ-specific autoimmunities or responses to pathogens in the context of a human immune system.
Research and quality control
We also provide extensive genotypic and phenotypic quality control and genetic stabilization for these strains, as well as incidence studies when available.
Origin of stocks
The resource includes strains generated at the Jackson Laboratory as well as strains donated by external scientists. Investigators are highly encouraged to donate a strain to ensure its preservation and availability to other researchers.