Targeted Mutation Stocks (Knockouts, Knockins and conditional Knockouts)

Common Name Strain Designation Stock Number
NOD.Casp1 KO NOD.129S2(B6)-Casp1tm1Sesh/LtJ 004947
NOD.Ins2 KO NOD.129S2(B6)-Ins2tm1Jja/GseJ 005036
NOD.Rag1 BDC12-4.1 NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J 009377
NSG-A2 NOD.Cg-Prkcdscid Il2rgtm1Wjl Tg(HLA-A2.1)1Enge/SzJ 009617
NSG-B2m NOD.Cg-Prkdcscid B2mtm1Unc Il2rgtm1Wjl/SzJ 010636
NOD.Myd88floxed NOD.Cg-Myd88tm1Defr/J 012622
B6-ApoE-/-, Akita B6.Cg-Apoetm1Unc Ins2Akita/J 013040
NOD.S1Pr1floxed NOD.129S6(B6)-S1pr1tm2Rlp/JbsJ 013063
D2-ApoE-/-, Akita D2.Cg-Apoetm1Unc Ins2Akita/J 013719
NOD.Alox15 NOD.129S2(B6)-Alox15tm1Fun/NadlJ 014163
NOD.P2rx7 NOD.129P2(B6)-P2rx7tm1Gab/DvsJ 015809
NOD.scid, Alox15 NOD.Cg-Prkdcscid Alox15tm1Fun/NadlJ 016148
NOD-iDTR NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ 016603
NOD.Cd18 null NOD.129S7(B6)-Itgb2tm2Bay/CgkJ 016897
NOD.CD11a NOD.129S7(B6)-Itgaltm1Bll/CgkJ 016898

 NOD.B2m

NOD.129P2(B6)-B2mtm1Unc/J

 002309

 NOD.IFNnull NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 002575

 NOD.Cd4null  NOD.129S6(B6)-Cd4tm1Knw/DvsJ

 003090

 NOD.Pfp

NOD.B6-Prftm1Sd/J

 003505

 NOD.IL4null

NOD.129P2(B6)-Il4tm1Cgn/DvsJ

 004222

NOD.IL-10null

NOD.Cg-Il10tm1Cgn/DvsJ

004266
NOD.IL4/10null

NOD.Cg-Il10tm1CgnIl4tm1Cgn/DvsJ

004291
 NOD.CD38  NOD.129P2(B6)-Cd38tm1Lnd /LtJ

004311

NOD.IF NRBnull

NOD.129S1(B6)-Ifngr2tm1Pbro/DvsJ

004352
NOD.Tcratm1

NOD.129P2(C)-Tcratm1Mjo/DoiJ

004444
NOD.C2ta

NOD.129S2(B6)-C2tatm1Ccum/FlvJ

004448
NOD.Igh-6   NOD.129S2(B6)-Igh-6tm1Cgn/DoiJ 004639
 NOD.Stat4  NOD.129S2-Stat4tm1Gru/JbsJ

 004671

NOD.Stat6    NOD.129S2-Stat6tm1Gru/JbsJ 004672
NOD.B7-1/Rag1 NOD.129(B6)-Rag1tm1MonCd80tm1Shr/JbsJ

004673 

NOD.CD28 KO NOD.129S2(B6)-Cd28tm1Mak/JbsJ

004761

NOD.B7-2  NOD.129S4-Cd86tm1Shr/JbsJ

004762

 NOD.Itgb7, Sell  NOD.Cg-Selltm1TftItgb7tm1Cgn/LtJ  004943
 NOD.Igtb7  NOD.B6-Itgb7tm1Cgn /2Lt  004944
 NOD.Ins1  NOD.129S2(B6)-Ins1tm1Jja/GseJ

005035

 NOD.OX40L  NOD.129(B6)-Tnfsf4tm1Shr/DoiJ

005075

 NOD.IL1r1  NOD.Cg-Il1r1tm1Roml/HetJ

 005078

 NOD.Ica1  NOD.129-Ica1tm1Mdos/MdosJ

 005080

 NOD.Ctla4  NOD.129(B6)-Ctla4tm1All/DoiJ

 005144

NOD.RAG1, CD80/86  NOD.Cg-Rag1tm1MomCd86tm2Shr/JbsJ

 005273

NOD.CD38, scid NOD.Cg-Cd38tm1LndPrkdcscid/LtJ

005345

NOD.IL10, Casp1

NOD.Cg-Il10tm1CgnCasp1tm1Sesh/LtJ

005346

NOD.B2m, C2ta KO NOD.129(B6)-B2mtm1UncC2tatm1Ccum/BhsJ

005356

NOD.Cd8a  NOD.129S2(B6)-Cd8atm1Mak/DvsJ

005513

BALB.Ncb5or  C.129S4-Cyb5r4tm1Hfb/HfbJ  005516
B6.Ncb5or  B6.129S4-Cyb5r4tm1Hfb/HfbJ

005517

NOD-Ins2 Tg3, Ins1KO, Ins2KO

NOD.Cg-Tg(Ins2*Y16A)3Ell Ins1tm1Jja Ins2tm1Jja/GseJ

005525

NOD.ICAM1

NOD.129S4(B6)-Icam1tm1Jcgr/SmtnJ

005983

NOD-Ins2Tg1, Ins1KO, Ins2KO

NOD.Cg-Tg(Ins2*Y16A)1Ell Ins1tm1Jja Ins2tm1Jja/GseJ

005524

NOD.DQ8, Ab0 NOD.Cg-Ab1tm1GruTg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/EllJ

006021

NOD.DQ8, Ab0, Rag1

NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/EllJ

006022

NOD.DQ6, Ab0 NOD.Cg-H2-Ab1tm1Gru Tg(CD4, HLA-DQA1, HLA-DQB1)N8Ell/EllJ

006023

NOD.DQ6, Ab0, Rag1

NOD.Cg-Rag1tm1MomH2-Ab1tm1Gru Tg(CD4,HLA-DQA1, HLA-DQB1)N8Ell/EllJ

006024

NOD.Cd1d KO

NOD.129S2(B6)-Cd1d1/Cd1d2tm1Spb/SbwJ

006330

NOD.ICAM1 KO (clean) NOD.129S4(B6)-Icam1tm1Jcgr/J

006251

NOD.Aire KO NOD.129S2(B6)-Airetm1.1Doi/DoiJ

006360

NOD.IgHEL, Igh -/- NOD.Cg-Igh-6tm1Cgn Tg(IghelMD4)4Ccg/DvsJ

006608

NOD.B2m-/- HHD NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ

006611

NOD.IL4 knockin NOD.Il4tm1Lky/JbsJ

006698

B6.Bdkrb2-/-, Akita B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ

006860

NOD.Vdr NOD.Cg-Vdrtm1Ska/CmatJ

006956

NOD.Cat B NOD.129P2(B6)-Ctsbtm1Jde /RclJ

008051

NOD.Art2 KO NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn /LtJ

008252

NOD.Cat L NOD.129P2(B6)-Ctsltm1Cptr/RclJ

008352

NOD.Cat S NOD.D1(B6)-Ctsstm1Eae/RclJ

008524

NOD.GFAP-B2m NOD.Cg-B2mtm1Unc Tg(GFAP-B2m)9Mdos/J

008542

NOD.Yet40

NOD.129(B6)-Il12btm1Lky/JbsJ

009618

NOD.H24/HHD NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A24/H2-D/B2M)3Dvs/J

010565

NOD.H2-Ab1 null NODCaj.129S2(B6)-H2-Ab1tm1Doi/LwnJ

010966

B6.Bdkrb1/2 KO C57BL/6-Bdkrb1/Bdkrb2tm1Mki/J

012371

Please Note: 

The Type 1 Diabetes Resource does not hold all the stocks at The Jackson Laboratory relevant to type 1 diabetes research. Visit this link to see a compiled list of type 1 diabetes mouse models held by JAX® Mice.

Last Modified: January 10, 2014