Verification of markers at known diabetes susceptibility/resistance (Idd) loci
As an extension of the genome scan, we concentrate on all reported diabetes susceptibility/resistance loci in a separate genomic microsatellite analysis for stocks in which a congenic interval, transgene or gene knockout have been introduced from another strain into NOD (or NOD genome introduced into a diabetes resistant background). The markers used allow allele distinction between most donor and recipient strains. It should be noted that not all Idd susceptibility alleles are NOD in origin (e.g., Idd7 on Chromosome 7 and Idd14 on Chromosome 13).
The following table is a listing of the markers used:
|
Chromosome |
Idd |
Markers Used |
|
1 |
Idd5 |
D1Mit18 and D1Mit180 |
|
2 |
Idd13 |
D2Mit395, D2Mit17 and D2Mit525 |
|
3 |
Idd3 |
D3Nds6 and D3Mit95 |
|
3 |
Idd10/17/18 |
D3Mit95, D3Mit100, and D3Mit345 |
|
4 |
Idd9 |
D4Mit203 |
|
4 |
Idd11/25 |
D4Mit203 and D4Mit59 |
|
5 |
Idd15 |
D5Mit346 and D5Mit48 |
|
6 |
Idd6/19/20 |
D6Mit31, D6Mit135 and D6Mit198 |
|
7 |
Idd7 |
D7Mit20 and D7Mit328 |
|
9 |
Idd2 |
D9Mit25 |
|
10 |
unnamed |
D10Mit87 |
|
11 |
Idd4 |
D11Mit339 and D11Mit298 |
|
13 |
Idd14 |
D13Mit16 and D13Mit61 |
|
14 |
Idd8 |
D14Mit110 |
|
14 |
Idd12 |
D14Mit222 |
|
17 |
Idd1/16 |
D17Mit34 |
|
18 |
Idd21 |
D18Mit171, D18Mit202, D18Mit208 and D18Mit4 |
|
|
|
We are always in seach of additional markers polymorphic between NOD, 129, and C57BL/6. If you know of any we do not currently include, please email the T1DR Project Manager (t1dr-info@jax.org) with this information.
Other GQC efforts in the T1DR:
