Because environment is a potent modulator of type 1 diabetes (T1D) gene penetrance, the T1DR will determine if the reported ability of a stock, and the particular genetic modification, to modulate T1D is retained under full barrier health status. Incidence studies will be performed to determine frequency and rate of mice of each sex, as well as NOD/LtJ.
In the past, NOD/LtJ mice in The Jackson Laboratory's production colonies developed diabetes at a 90-100% incidence over 30 weeks of age for females and a 40-60% diabetes incidence over 30-40 weeks of age for males. However, in 2006 the incidence was somewhat attenuated (females 65%, males 35%), very likely reflecting stress associated by campus wide blasting associated with construction and in 2008 the incidence is higher than we normally see (females 90%, males 85%), likely reflecting a room environment where the lights were on 24 hours a day for an undetermined amount of time, most likely several months. We are currently monitoring incidence studies for our colony of NOD/LtJ as well as other T1DR strains in our full barrier, sterile supply, specific-pathogen-free (SPF)) facility. These mice are housed in Pressurized Individually Ventilated (PIV) racks in a room dedicated to immuno-compromised stocks with minimal disturbance.
Incidence studies are available for the following strains:
Last Modified: August 01, 2012