David Serreze, Ph.D., Principal Investigator
Dr. Serreze's laboratory investigates the genetic control mechanisms allowing the immune system to recognize and destroy foreign pathogens, but not normal constituents of the body. Defects in these mechanisms underlie many autoimmune diseases, including type 1 (juvenile onset, insulin dependent) diabetes. Using non-obese diabetic inbred mice, Dr. Serreze studies the process through which genes that normally elicit immune responses to foreign intruders can sometimes trigger autoimmune responses against the body's own cells, such as the pancreatic cells that make insulin.
Racheal Wallace, Manager, Type 1 Diabetes Repository
Edward Leiter, Ph.D., Emeritus Director and Advisor
Dr. Leiter's research career concentrated on the interaction between genetic and environmental factors that predispose inbred mouse strains to the development of both type 1 insulin-dependent diabetes (T1D), and type 2 diabetes. While retiring from bench research, Dr. Leiter will continue to be involved with diabetes resource development and management under the aegis of the Type 1 Diabetes Resource (T1DR).
Through many years of experience, T1DR staff have a great deal of expertise in working with diabetic mice. If you cannot find the information you are looking for on this site, please contact us.
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